Hum Vaccin Immunother. 2016 May 12:1-5.

Is HPV vaccination in pregnancy safe?

Bonde U, Joergensen JS, Lamont RF and Mogensen O


Millions of doses of HPV vaccine have been administered globally. Inadvertent administration of HPV vaccine during pregnancy occurs given that the main recipients of the vaccine are fertile young women, who might be unaware of their pregnancy at the time of their vaccination. To investigate the subject of HPV vaccine and pregnancy, the databases of PubMed and Embase were searched to find the relevant literature published in English within the last 10 y. Most of the evidence pertaining to fetal adverse events following HPV vaccination relates to spontaneous miscarriage. None of the relevant studies found any significantly increased rate of spontaneous abortion in the overall analyses. There was no indication of other HPV vaccine-associated adverse events in pregnancy or immediately post-conception.

Comment: Often women ask if they can have the HPV vaccine, when they are already pregnant. Later they come back and ask if an abortion is indicated. The huge database search now published, shows that there is no reason to worry about any adverse events, either to the mother or to her baby. (HMV)