Creatinine is a product of
muscle metabolism. It is produced at a nearly constant rate and is
excreted in the urine.
If kidney function is significantly reduced, the urine creatinine will
fall. With more severe degrees of kidney failure, the serum creatinine
will eventually rise.
Vigorous exercise or muscular trauma occurring during the collection
will cause an increased amount of creatinine in the blood.
Creatinine may be elevated in:
- Impaired renal function
- Muscle disease
- Diabetic ketoacidosis
- Diet unusually high in meat products
- Excessive Vitamin C intake
*These are general values taken from a variety of
sources. The actual normal values may vary from lab to lab and from one
type of testing protocol to another.