Piroxicam (Feldene)

Category:

Analgesic

Description:

Nonnarcotic angalgesic, nonsteroidal antiinflammatory drug (NSAID)

Indications:

Osteoarthritis
Rheumatoid arthritis

Precautions:

Pregnancy category B (avoid administration near term); excreted into breast milk, but should not present risk to infant
Children, bleeding disorders
GI disorders, cardiac disorders
Asthma, renal or hepatic disease
Elderly

Adverse Reactions (Side Effects):

CNS: anxiety, confusion, depression, dizziness, drowsiness, fatigue, headache, insomnia, tremors
CV: dysrhythmias, palpitations, peripheral edema, tachycardia
EENT: blurred vision, hearing loss, tinnitus
GI: anorexia, bleeding, cholestatic hepatitis, constipation, cramps, diarrhea, dry mouth, flatulence, jaundice, nausea, perforation, ulceration, vomiting
GU: nephrotoxicity
HEME: blood dyscrasias
SKIN: photosensitivity, pruritus, purpura, rash, sweating

Dosage:

Administered orally

Adult: PO 20mg once daily or 10mg 2 times daily

Drug interactions:

Anticoagulants: addition of piroxicam associated with excessive hypoprothrombinemia and bleeding; ibuprofen less likely to interact
Methotrexate: addition of piroxicam may interfere with the renal secretion of methotrexate, yielding increased risk of methotrexate toxicity

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300