Table 1. Overview of Outcomes of Labor Induction Abortion Methods


Method Ref Success 12 hr (%) Success 24 hr (%) Success 48 hr IAT* (hs) >20 wk Retained Placenta (%) Total Curettage (%) Hemorrhage (%) Transfusion (%) Coagulopathy (%) Cervical Injury (%) Nausea (%) Vomiting (%) Diarrhea (%) Fever (%) Infection (%)
Intra-Amniotic Instillation
Saline 8   20 81 30 Yes   32 1.5 .8     .8 19 1    
Saline + oxytocin 7,9       21–26 Yes 13–15   2 .5–2 .3 .3–4       5 2–3
Saline + PGF + oxytocin 16 63 94   16.1 Yes 24   2 2 1 0 48 33 1 3  
Urea + oxytocin 10,11,12     97 19–29 Yes 18–19   5 .7 .2 .3–1   53 1 1 2–9
Urea + PGF + oxytocin 9,10,17   85–93   12–17 Yes 10   6–10 .3–2   1–3   73 5 6 5–6
Urea + 15-MPGF + laminaria 18   97   13.2 Yes     2 0   .2   34 13   5
PGE2 + oxytocin 13 45–54 88–90   14.5–15.5 yes   25 2 .7   .3   39 5   .4
PGF 8,15   54–68 82–87 19.7 yes   41 3–5 3   3   2 1–15    
PGF + oxytocin 19,20 20 95 97 15.6–16.6 yes 64 71 10 5–16   3   48–50 26–33   .4
15-MPGF 15   72–76 93–96 18–20 No     1–2     3   1.5 .5    
Extra-Amniotic Administration
PGE2 + oxytocin 13,19,20 25 78–90 93 14–17.6 Yes 39 35–42 2–10 1–10   0–.06   24–45 11–17 0 .2–3
Ethacridine lactate 22,23   69–82 99 15.8 Yes 4   2   2   4       5
Vaginal Administration
PGE2 24,25,26,27,28,29,30 50 86–93   13 Yes 42 21–68 0–2 2     46–62 30–54 15–40 20–64 1
Gemeprost 31,32,33,34   74–88 92–100 14.5–19.3 No 20–54 64–78 1–2 1–4   .1–2   14–23 20–26 14–18 .1
Misoprostol 29,35,39,42,46   59–89 60–100 12–28 Yes   8–57 0 0     28–37 4–28 2–14 8–11 0
Mifepristone (mife) Regimens
Mife 200 mg + gemeprost 57,59   88–98 99–100 7.5–10.8 Yes 24 18–40   0–1   1 44 16–44 4–44    
Mife 200 mg + vaginal miso 59,60,61,63 82–88 84–97 100 6.0–10.0 No 9 11–25 3 0     32 52–61 25–56 12  
High-Dose Oxytocin
Oxytocin 24, 25   80–91   8.2–12.6 Yes             33 18 0 0  

*AT = induction to abortion time (mean or median)