Fig. 8. Adenocarcinoma in situ, endocervical type. ( A) The neoplastic glands retains the branching and budding pattern of normal endocervical glands. These glands have smooth borders and are surrounded by normal fibromuscular stroma without desmoplastic reaction. At the base of tumor, malignant cells replace normal endocervical cells. ( B) Higher magnification to reveal tall columnar neoplastic cells with nuclear stratification, hyperchromasia, elongation, and irregularity. (Hematoxylin-eosin stain, original magnification A: 40, B: 100.)