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Maternal sepsis

Severe infection during pregnancy, at birth or
after birth

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Written by experienced doctors, midwives and other medical professionals – and approved by a specialist Editorial Board

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Enhancing the Welfare of Women

Expert Health Information for Women

Maternal Sepsis
Severe infection during pregnancy, at birth or after birth
When you are pregnant or have recently been pregnant, you are more likely to get a serious infection or sepsis. This can happen if an infection during pregnancy, birth or after the baby is born spreads through your body.
If not treated quickly, sepsis can be very dangerous. It can affect important parts of your body and can even cause death.
If you have a high fever, fast heartbeat, trouble breathing, or feel very weak, dizzy or confused, go to your nearest healthcare facility as soon as possible.
You are more likely to get sepsis if you have had a cesarean section, if your waters break more than 1–2 days before the baby is born, you have had a long labor or if you have an infection.
Sepsis is more common in women who have diabetes, are overweight, are carrying more than one baby, have a weak immune system (for example have HIV) or have had multiple urine infections during pregnancy.
To help prevent sepsis, it is important that you go to your pregnancy check-ups, wash your hands often and stay up-to-date with your pregnancy vaccines. 
If you are unwell, your healthcare worker will ask you some questions, examine you, and order some tests.
If you have an infection, your healthcare worker will give you antibiotics through a drip to fight the infection, and fluids through a drip to keep your body hydrated. You should start treatment within an hour.
Your healthcare worker should wash their hands with soap often and make sure you give birth in a clean and safe place to protect you and the baby.
Keep any wounds clean, especially after a cesarean section. Wash with clean water and cover wounds with a clean dressing.
You may need to stay in the hospital to be monitored, and sometimes your baby may also need to be monitored.
These steps can help protect you and your baby from dangerous infections that cause sepsis.

The authors of this MATERNAL SEPSIS program are:

  • Bossy Farag
    University of Liverpool, United Kingdom
  • Dr Kate Lightly
    University of Liverpool, United Kingdom
  • Dr Laura Goodfellow
    University of Liverpool, United Kingdom
  • Bertha Maseko
    Malawi Liverpool Wellcome Research Programme, Malawi

The Welfare of Women program has been created under the General Editorship of Dr Kate Lightly, University of Liverpool, UK and is overseen by an expert International Editorial Board

The cost of producing this resource has been partly funded by an educational grant from GSK

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What is maternal sepsis?

Infections are common during pregnancy, birth and after birth. Sometimes, these infections can enter the blood, spread quickly through the body and damage major organs. When this happens, it is called maternal sepsis. If it is not treated quickly, maternal sepsis can be very dangerous and even life-threatening.

Why is it important to know about maternal sepsis?

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Maternal sepsis is one of the main causes of death in women during pregnancy, childbirth and after birth. It can also affect your baby, causing an early birth or sometimes infections in the baby or death.

It can be lifesaving to learn about sepsis so that you know when to go to a healthcare facility if you think that you have sepsis. With the proper care, sepsis can be treated and your life and your baby's can be saved.

What are the causes of maternal sepsis?

Infections are the most common cause of maternal sepsis. These infections can happen:

  • in wounds, especially after cesarean section
  • in the womb after birth
  • in the water around the baby during pregnancy
  • elsewhere in your body, for example, in your kidneys, breasts or chest

You may also be more at risk of maternal sepsis if you

  • have an untreated infection
  • have a cesarean section or vaginal tear during birth
  • give birth in a place without access to clean water or where it is hard to keep clean
  • give birth in a place that is overcrowded
  • have a long birth
  • your waters break more than a day before the baby is born
  • have a weak immune system, for example, because of HIV
  • have urine infections during pregnancy
  • are overweight
  • have diabetes
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What are the symptoms of maternal sepsis?

You might have maternal sepsis if you

  • have a fever or feel cold and shivery
  • have a fast heartbeat
  • have trouble breathing or are breathing fast
  • feel very weak, tired and dizzy
  • feel confused
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Especially if you

  • notice bad-smelling discharge passing from your vagina
  • notice swelling, redness, pain and discharge from your cesarean section wound

If you notice any of these symptoms, you need to go to your nearest healthcare facility straight away. Do not wait. Sepsis can get worse quickly and can even end your life.

How is maternal sepsis treated?

If you think you have maternal sepsis, your healthcare worker will check you and your baby and

  • ask you some questions about how you feel
  • examine you to assess your general wellbeing
  • measure your blood pressure, temperature, heart rate and breathing rate
  • arrange some tests such as blood tests

To treat maternal sepsis, your healthcare worker may give you

  • antibiotics through a drip to fight the infection
  • salty water through a drip to keep you hydrated

Treatment for sepsis should start as soon as possible, preferably within an hour of it being recognized. You may need to stay in the hospital to be monitored, and the baby may be born early.

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How to prevent maternal sepsis?

You can lower your chances of maternal sepsis by

  • treating any infections early
  • going to all of your pregnancy check-ups
  • staying up-to-date with your vaccinations
  • washing your hands often with soap and having good hygiene
  • keeping any wounds clean, especially cesarean section wounds, by washing them with clean water
  • giving birth in a clean and safe space
  • making sure that your healthcare worker washes their hands before touching you or your baby

These steps can help protect you and your baby from dangerous infections that cause sepsis.


The authors of this MATERNAL SEPSIS program are:

  • Bossy Farag, University of Liverpool, United Kingdom
  • Dr Kate Lightly, University of Liverpool, United Kingdom
  • Dr Laura Goodfellow, University of Liverpool, United Kingdom
  • Bertha Maseko, Malawi Liverpool Wellcome Research Programme, Malawi

The Welfare of Women program has been created under the General Editorship of Dr Kate Lightly, University of Liverpool, UK and is overseen by an expert International Editorial Board

The publishing reference for this program is: DOI 10.3843/GLOWM.w10093

The Welfare of Women information program is an attempt to provide women everywhere with access to reliable information about key health issues that may be relevant to them. Information is offered at three separate levels which women may select according to their preferences; firstly, short video animations with voice commentary, secondly, more detailed text-based descriptions, and thirdly, links to recommended further reading. With the animated videos, women can also select the images that they feel most comfortable in viewing from a short range of very generalized and non-specific ethnicity options. Because of the special programming used, both the videos and the text information can – when authorized – be translated into any language in a simple and rapid manner.

Recommended links for more comprehensive and detailed reading

Resources the author(s) used in preparing this guidance